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VHL Ligand 3

CAS No. 1448189-98-7

VHL Ligand 3( —— )

Catalog No. M11911 CAS No. 1448189-98-7

A VHL ligand for PROTAC.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VHL Ligand 3
  • Note
    Research use only, not for human use.
  • Brief Description
    A VHL ligand for PROTAC.
  • Description
    A VHL ligand for PROTAC.
  • In Vitro
    The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional PROTACs to induce ubiquitination and subsequent proteasomal degradation of a target protein.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    E3 Ligase Ligand
  • Recptor
    E3 Ligase Ligand
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1448189-98-7
  • Formula Weight
    530.684
  • Molecular Formula
    C27H38N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (188.44 mM)
  • SMILES
    ——
  • Chemical Name
    tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wurz RP, et al. J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.6b01781. 2. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
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