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VHL Ligand 3
CAS No. 1448189-98-7
VHL Ligand 3( —— )
Catalog No. M11911 CAS No. 1448189-98-7
A VHL ligand for PROTAC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameVHL Ligand 3
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NoteResearch use only, not for human use.
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Brief DescriptionA VHL ligand for PROTAC.
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DescriptionA VHL ligand for PROTAC.
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In VitroThe VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional PROTACs to induce ubiquitination and subsequent proteasomal degradation of a target protein.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetE3 Ligase Ligand
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RecptorE3 Ligase Ligand
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Research Area——
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Indication——
Chemical Information
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CAS Number1448189-98-7
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Formula Weight530.684
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Molecular FormulaC27H38N4O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (188.44 mM)
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SMILES——
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Chemical Nametert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wurz RP, et al. J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.6b01781.
2. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
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